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Hot picks for NFL Week 1 games

It's not too early to start thinking of those Week 1 picks in the NFL, as the first game takes place on September 10 as the Pittsburgh Steelers head to New England for a Thursday night tilt.

Let's take a look at some of the current lines.

Pittsburgh (+3) at NEW ENGLAND

This is an intriguing decision by Vegas to give the Steelers points when they might be taking on a backup quarterback in Jimmy Garoppolo. Garoppolo has been serviceable in the postseason, but it's difficult to imagine Pittsburgh not pinning back their collective ears and making their lives miserable. If Brady's suspension remains in place, take Pittsburgh and the points all night long. If Brady returns, though, back the Pats as this line may shift even more in the Pats' favor as bettors take advantage of that fan energy that will pulsate through Gillette Stadium.

Kansas City (+1.5) at HOUSTON

The big question for the Texans is how new starting quarterback Brian Hoyer will play. He was inconsistent with the Browns but won coach Bill O'Brien over in training camp, taking the starting job from Ryan Mallett. The Chiefs have a game manager (Alex Smith) at quarterback. Expect them to play well, but take the Texans with this low point spread as their home energy should carry them.

Indianapolis (-2.5) at BUFFALO

Given the fact that Rex Ryan will have the Buffalo defensed amped up, and given that the Bills have had all three quarterbacks playing extremely well in the preseason, I would take the Bills here. I see them jumping all over Andrew Luck and sending the Colts home.

Green Bay (-6.5) at CHICAGO

John Fox brings enthusiasm to Soldier Field, but he still only has Jay Cutler at quarterback. Even without Jordy Nelson, the Pack should win this by at least a touchdown.

Carolina (-3) at JACKSONVILLE

Interesting matchup given the stellar play of Blake Bortles in the preseason for the Jags. However, look to that Panthers' D to take over the game and take this game by more than three.

Cleveland (+3) at NEW YORK JETS

The Jets will be throwing the league's best secondary at Josh McCown, who was terrible with Tampa last year. If McCown falters, it will be Johnny Manziel. Take the Jets to do more than cover.

Miami (-3.5) at WASHINGTON

Pick Ndamukong Suh to sack Kirk Cousins at least three times – and for the Dolphins to be all over the Redskins.

Seattle (-3.5) at ST. LOUIS

After that horrendous Super Bowl loss, look for Seattle to be ready to avenge that debacle – as well as get revenge to the Rams for seeking out a two-point win against the Seahawks in St. Louis last year. Those special teams fakes won't work quite so well this year.

Detroit (-2.5) at SAN DIEGO

Tough call here. The Lions still have a stout pass rush, but the Chargers may be motivated behind Philip Rivers to do more than be an enigma. Since the Chargers are at home, I would take them to cover.

New Orleans (+2.5) at ARIZONA

The Saints are tough at home, not so much on the road. Arizona has Carson Palmer back and may be on the way to another 9-1 start. Take the Cards to cover.

Cincinnati (-3.5) at OAKLAND

If this game were at night, given Andy Dalton's night woes, I would pick Oakland. I would pick them anyway, since I expect the Bengals to still be caught in a malaise and Derek Carr to find Amari Cooper all over the field.

Baltimore (+4) at DENVER

Given Peyton Manning's struggles in the preseason, it would not surprise me to see Baltimore come in and win this game straight up, not just against the spread.

Tennessee (+2.5) at TAMPA BAY

Great game to watch, featuring Mariota vs. Winston. Tampa Bay wins this, not because Winston is better but because the Bucs' defense is much better.

New York Giants (+5) at DALLAS

Expect Dez Bryant to run wild in his first action since The Catch That Wasn't. The Giants are missing Jason Pierre-Paul and haven't looked together in the preseason. Take the Cowboys to cover.

Philadelphia (-2) at ATLANTA

The Eagles have looked solid on both sides of the ball this preseason. Expect that to continue in the Georgia Dome.

Minnesota (-2) at SAN FRANCISCO

The return of Adrian Peterson and the growth of Teddy Bridgewater make this a huge night for the Vikings.

Click here to get the latest NFL odds at Mybookie

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