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Monday NFL Prediction: San Francisco 49ers vs. Arizona Cardinals

49ers Cardinals

Our 49ers vs. Cardinals prediction will let you know the NFL point spread bet to make in the Monday Night Football game.


The San Francisco 49ers (5-2) will head into the desert to take on the Arizona Cardinals (4-3) at University of Phoenix Stadium in this week’s Monday Night Football game, and our preview will break down both teams before releasing a prediction on the eventual winner.  The 49ers vs. Cardinals game will be shown on the ESPN channel with a start time of 8:30 PM ET on October 29th.


San Francisco’s only 2 losses of the season have come against strong defensive teams (New York Giants and the Minnesota Vikings) and the Cardinals also have the ability to limit this offense.  Arizona hasn’t given up more than 21 points all season and they’ve done it while playing upper-end offenses like the Buffalo Bills, New England Patriots, and Philadelphia Eagles.


The Cardinals’ issue lately is their lack of offense, and that doesn’t figure to improve much here.  Arizona has score no more than 16 during their current 3-game losing streak against the Bills, the Vikings, and the St. Louis Cardinals, and the offense simply hasn’t shown anything resembling the early season promising start.  The 49ers have given up a total of 9 points combined over their last 3 games and should be able to shut down Arizona’s offense on Monday Night Football.


San Francisco had won 5 in a row against the Cardinals before the most recent clash in 2011 when Arizona won 21-19 at home despite being a 3.5-point underdog.  The 49ers had covered the point spread in 6 straight head-to-head meetings against the Cardinals before that point, and San Francisco won 23-7 at home as a 10-point underdog earlier in 2011.  The under has been a winner in 4 of the last 6 between these NFC West rivals.


Betting odds on the Monday Night Football game have the road-team 49ers as a 7-point favorite, while the total at 5Dimes Sportsbook currently sits at 38.5.  Those that want to bet on Monday Night Football should do so at 5Dimes Sportsbook since they are currently offering our readers a 50% cash bonus to anyone that clicks on the link in this paragraph to get signed up!


Ultimately the Monday Night Football prediction calls for a low-scoring game that will largely be determined by the team that does a better job of limiting turnovers and mistakes.  San Francisco quarterback Alex Smith has been shaky lately, but he’s still much stronger than Arizona counterpart John Skelton at managing the game.  The 49ers have more options on offense and their defense should be able to force turnovers and give the offense quality field position throughout.  The best NFL bets to make here are going to be on the 49ers and the under.


49ers vs. Cardinals Prediction:


San Francisco 49ers 20

Arizona Cardinals 10

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